Abstract
The role of the 5-hydroxytryptamine (5-HT) receptor subtypes in the spinal cord in the regulation of nociception is unknown. This study examined whether administration of different 5-HT 1 receptor agonists into the spinal subarachnoid space of mice modulates the nociceptive tail-flick reflex, and whether effects on the tail-flick reflex involve changes in tail skin temperature. The tail-flick latencies (the time needed to evoke the tail-flick reflex by noxious radiant heat) were significantly increased after intrathecal (i. th.) injection of 5-HT (10–20 μg), the 5-HT 1A/5-HT 1B receptor agonist 5-methoxy-N,N-dimethyltryptamine (5-MeODMT, 10–20 μg), the selective 5-HT 1A receptor agonist 8-hydroxy-2-di-n-propylamino)tetralin (8-OH-DPAT, 20 μg), and after i.th. injection of 1(m-chlorophenyl)piperazine (mCPP, 5–20 μg) and 5-methoxy-3(1,2,3,6-tetrahydropyridin-4-yl)-1H-indole (RU 24969, 5–20 μg) which have high affinity for the 5-HT 1B receptors. None of the 5-HT 1 receptor agonists had the ability to change the tail skin temperature. The results show that in the mouse i.th. injection of both 5-HT 1A and 5-HT 1B receptor agonists has the ability to inhibit the tail-flick reflex without interfering with the tail skin temperature.
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