The Role of Single Nucleotide Variants of NOS1, NOS2, and NOS3 Genes in the Development of the Phenotype of Migraine and Arterial Hypertension.

Polina V Moskaleva,Natalya A Shnayder,Marina M Petrova,Regina F Nasyrova,Victoria B Sharavii,Daria S Kaskaeva,Elena E Vaiman,Natalia P Garganeeva,Sergey V Radostev,Oksana A Gavrilyuk

doi:10.3390/brainsci11060753

Polina V Moskaleva, Natalya A Shnayder + Show 8 more

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https://doi.org/10.3390/brainsci11060753

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Abstract

Migraine (M) and arterial hypertension (AH) are very common diseases. Today, there are a number of studies confirming and explaining their comorbidity. We searched PubMed, Springer, Scopus, Web of Science, Clinicalkeys, and Google Scholar databases for full-text English publications over the past 15 years using keywords and their combinations. The present review provides a synthesis of information about single nucleotide variants (SNVs) of NOS1, NOS2, and NOS3 genes involved in the development of M and essential AH. The results of studies we have discussed in this review are contradictory, which might be due to different designs of the studies, small sample sizes in some of them, as well as different social and geographical environments. Despite a high prevalence of the M and AH phenotype, its genetic markers have not yet been sufficiently studied. Specifically, there are separate molecular genetic studies aimed to identify SNVs of NOS1, NOS2, and NOS3 genes responsible for the development of M and those responsible for the development of AH. However, these SNVs have not been studied in patients with the phenotype of M and AH. In this review, we identify the SNVs that would be the most interesting to study in this aspect. Understanding the role of environmental factors and genetic predictors will contribute to a better diagnostics and exploration of new approaches to pathogenetic and disease-modifying treatment of the M and AH phenotype.

Highlights

Arterial hypertension (AH) is a common disease worldwide and is a key risk factor for fatal cardiovascular complications [1]
Scholar databases for full-text English publications over the past 15 years using such keywords and their combinations as nitric oxide, nitric oxide synthase, NOS1, NOS2, NOS3, genes, single nucleotide variants, single nucleotide polymorphisms, comorbidity, arterial hypertension, and migraine
We summed up single nucleotide variants (SNVs) of NOS1, NOS2, and NOS3 genes involved in the development of migraine and essential arterial hypertension (AH)

Summary

Introduction

Arterial hypertension (AH) is a common disease worldwide and is a key risk factor for fatal cardiovascular complications [1]. Many studies support the hypothesis that patients with M have an increased risk of developing AH, while patients with AH seem to have an increased risk of M. This allows us to hypothesize about the existence of the M and AH phenotype. The relationship between M and AH is potentially of great pathophysiological and clinical interest and is being actively studied. The pathophysiological pattern is significantly different in the setting of chronic pain, in which the adaptive relationship between blood pressure and pain sensitivity changes significantly. The association between acute or chronic pain and

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