The Role of Resistin, IL-6 and NH2-Terminal Portion ProBNP in Pathogenesis of Cardiac Disease in Type 2 Diabetes Mellitus

Abstract

Background: The role of interleukin-6 (IL-6), Nt-pro BNP and resistin in the pathogenesis of heart disease in type 2 diabetic is still a matter of controversy. The current study aimed to declare the association between circulating levels of resistin, Nt-pro BNP and IL-6 and cardiac dysfunction in type 2 diabetes (T2DM) and to evaluate them as non invasive markers of Echocardiogenic changes. Methods: 150 participants shared in this study, 100 patients with T2DM and 50 healthy controls. According to echocardiographic findings, the patients were subdivided into 2 subgroups: Group 1a, includes 46 patients with T2DM and evidence of cardiac remolding and systolic dysfunction, and 54 patients were without Echocardiogenic changes as group 1b. Routine laboratory investigations were performed such as complete blood count, liver and renal function tests and lipid profile. Echocardiography was done to assess cardiac systolic function. Serum IL- 6, Nt-pro BNP and resistin were measured for all participants. Results: There was a significant increase in the levels of resistin, Nt-pro BNP and IL-6 in group 1a patients compared to 1b group and healthy controls. Echocardiograpgic parameters showed a significant increase of left ventricular mass index (LVMI), left ventricle posterior wall thickness (LVPW), inter-ventricular septum (IVS), left ventricle mass (LVM) in group 1a compared to group 1b and control group. The increased LVMI was associated with higher levels of IL-6, Nt-pro BNP and resistin. Conclusions: Pro-inflammatory cytokines play an important role in the diabetogensis and cardiac outcome in T2DM. They could be used as early non-invasive markers for cardiac remolding and systolic dysfunction in T2DM patients. Large scale future studies could be done to investigate the role of genetic polymorphism of these cytokines in development of cardiac stroke in DM. Funding Statement: The authors stated that they did not receive any funding. Declaration of Interests: The authors declare that there is no conflict of interest regarding the publication of this paper. Ethics Approval Statement: An informed written consent was obtained from all individual participants included in the study. The study was reviewed and approved by the ethical committee at the National Liver Institute.