Abstract
ObjectiveHigh expression of phosphorylated signal transducer and activator of transcription 3 (p-STAT3) has been detected in a variety of human tumors. However, the association of positive p-STAT3 expression with clinicopathological parameters and the prognosis of colorectal cancer patients remain controversial. To identify the relationship between p-STAT3 expression and clinicopathological parameters and prognosis in patients with colorectal cancer, a systematic review and meta-analysis were performed.MethodsWe performed a comprehensive literature search from PubMed, EMBASE, and SinoMed through 27 March, 2016. Hazard ratios (HRs) with 95% confidence intervals (CI) were combined to evaluate the association between p-STAT3 expression and overall survival of colorectal cancer patients. Odds ratios (ORs) with 95% CI were combined to evaluate the association between p-STAT3 expression and clinicopathological parameters in patients with colorectal cancer.ResultsSeventeen studies including a total of 2,346 colorectal cancer patients were included in this meta-analysis. The combined HR was 1.43 (95% CI: 1.23–1.67, P < 0.001), which suggested a positive relationship between p-STAT3 overexpression and poorer overall survival of colorectal cancer patients. In addition, the results indicated that positive p-STAT3 expression was significantly associated with the presence of lymph node metastasis (OR: 2.43, 95% CI: 1.18–5.01, P = 0.02) but was not associated with TNM stage, tumor differentiation or gender.ConclusionThe meta-analysis results suggest that p-STAT3 overexpression is unfavorable for the prognosis of colorectal cancer patients, and p-STAT3 overexpression is associated with the presence of lymph node metastasis among colorectal cancer patients.
Highlights
Colorectal cancer (CRC) represents close to 10% of global cancer incidence with an estimated 746 000 new cases in men and 614 000 new cases in women, and it was the fourth most common cause of death from cancer with an estimated 694 000 deaths worldwide in 2012
August 9, 2016 p-Signal transducer and activator of transcription 3 (STAT3) and Colorectal Cancer suggested a positive relationship between p-STAT3 overexpression and poorer overall survival of colorectal cancer patients
The results indicated that positive p-STAT3 expression was significantly associated with the presence of lymph node metastasis (OR: 2.43, 95% confidence intervals (CI): 1.18–5.01, P = 0.02) but was not associated with TNM stage, tumor differentiation or gender
Summary
Colorectal cancer (CRC) represents close to 10% of global cancer incidence with an estimated 746 000 new cases in men and 614 000 new cases in women, and it was the fourth most common cause of death from cancer with an estimated 694 000 deaths worldwide in 2012. The estimated new cases mainly occurred in Europe (32.9%), East and Central Asia (19.3%), and China (18.6%). The estimated deaths mostly occurred in Europe (31.0%), China (20.1%), and East and Central Asia (18.5%). The 5-year relative survival of colorectal cancer ranged from 65.5% (diagnosis in 1999–2003) to 66.1% (diagnosis in 2004–2010) [1]. Lifestyle, medications, smoking, obesity, and sedentary lifestyle were associated with an increased risk of colorectal cancer [2,3]. Genetic changes may play a crucial role in the pathogenesis of colorectal cancer
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