Abstract
The aim of this study was to evaluate the influence of cellular immunity parameters on overall survival of colorectal and gastric cancer patients after surgery. The parameters of cellular immunity (CD3+, CD4+, CD8+, CD20+, and CD16+) were determined by immunofluorescence method. Cox regression analysis showed no impact of the estimated preoperative and postoperative parameters of cellular immunity on overall survival of colorectal cancer patients and similarly of gastric cancer patients in stage II. However, the analysis showed that the survival of colorectal and gastric cancer patients in stage III depended on immunological parameters determined before surgery: CD3+ (P=0.007 and P=0.007, respectively), CD4+ (P=0.021 and P=0.011, respectively), and CD8+ (P=0.047 and P=0.007) counts. Only the survival of colorectal cancer patients depended on natural killer cell number (P=0.009). Kaplan-Meier analysis showed that patients with stage III colorectal and gastric cancer had better survival rates when absolute number of CD3+ lymphocytes, determined before surgery, was greater than 0.8 x 10(9)/L, CD4+--greater than 0.25 x 10(9)/L, CD8+--greater than 0.3 x 10(9)/L. Colorectal cancer patient survived longer when the number of natural killer cells CD16+ was more than 0.25 x 10(9)/L. This study suggests that higher levels of the absolute number of lymphocyte subsets before surgery have a beneficial effect on overall survival of gastric and colorectal cancer patients in stage III.
Highlights
The exact causes of digestive system cancer are not known, but risk of carcinogenesis appears to be associated with genetic, dietary, lifestyle factors and immunodeficiency disorders [1,2,3,4,5,6,7]
Cox regression analysis showed that only preoperative parameters of cellular immunity had an impact on overall survival of colorectal and gastric cancer patients in stage III, but postoperative parameters (14 days after surgery) had no impact
Cox regression analysis showed that colorectal cancer patients with a higher absolute number of CD16+ survived longer (P=0.009; b=–11.8)
Summary
The exact causes of digestive system cancer are not known, but risk of carcinogenesis appears to be associated with genetic, dietary, lifestyle factors and immunodeficiency disorders [1,2,3,4,5,6,7]. Tumor deepens an already existing disbalance of the immune system, and it is caused by an intricate array of local and systemic physiological responses [8]; patients with cancer have a variety of immunological abnormalities [9]. Surgery is the most frequent primary treatment for gastric and colorectal cancer. This treatment can deepen already existing injury in the immune system [9, 16]
Sign-in/Register to view highlights & summary 
Published Version (
Free)
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
