Abstract
The objectives of this mini-symposium are to present new evidence delineating the pivotal role of cellular protein kinases in the regulation of contraction- and training-induced alterations in muscle metabolism and in the development of metabolic pathologies such as insulin resistance and obesity. Dr Winder will present data on the role played by AMP-activated protein kinase in the regulation of muscle metabolism. With muscle contractions, AMP-activated protein kinase activity is increased and this has been shown to be associated with changes in not only fatty acid but also glucose metabolism. Results on the effects of alterations in insulin concentration, carbohydrate availability, and endurance training on AMP-activated protein kinase activity and on muscle metabolism will be presented. Dr Richter will present data collected in both human and animal studies on the role of AMP-activated protein kinase and glycogen synthase kinase-3 in the regulation of glycogen synthase activity at rest, during exercise and during recovery from exercise. The important role of glycogen content on glycogen synthase activity, subcellular location and kinase activity will be discussed. Perilipin is a phosphoprotein, which is located at the surface of intracellular lipid droplets. Activation of cAMP-dependent protein kinase (PKA) results in the phosphorylation of perilipin and hormone-sensitive lipase with concurrent stimulation of lipolysis. Dr Greenberg will present data indicating that both perilipin levels and its phosphorylation state are critical regulators of lipid storage and lipolysis.
Published Version
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