Abstract
Objective of this study was to determine whether single-nucleotide polymorphism (SNP) in mTOR gene is associated with development of allergic phenotype in children. Methods. Genotyping for mTOR (rs11121704) was performed in the following populations: patients with asthma (n = 91; ages 5–18 years), and control group (n = 87; ages 5–18 years) using real-time polymerase chain reaction. Results. We have found that 50 (54.9 %) of patients from the study group and 43 (49.4 %) subjects from the control group had major allele of rs11121704 in mTOR, 36 (39.6 %) and 32 (36.8 %), respectively, — heterozygous allele, and 5 (5.5 %) and 12 (13.8 %) — minor allele. Variants of rs11121704 minor genotype in the gene mTOR were 2.5 times more likely in the control group than among patients of the study group. Conclusions. We supposed that SNP in mTOR may independently serve as perspective marker to predict the development of asthma and other allergic diseases among children.
Highlights
Bronchial asthma has reached epidemic proportions throughout the world
Genotyping We found that single-nucleotide polymorphism (SNP) was in Hardy-Weinberg equilibrium
Evidence from the literature has established that mTOR function is necessary for Th1 and Th2 effector T cell differentiation and plays a critical role in eczema and possibly in the phenotype of eczema plus asthma
Summary
Bronchial asthma has reached epidemic proportions throughout the world. WHO estimated that 235 million people currently suffer from asthma. Asthma is the most common noncommunicable disease among children. The main risk factors for developing asthma are a combination of genetic predisposition with environmental exposure. Nowadays we can observe great improvements in childhood environment, care of children, diagnostic and treatment measures that led to decreasing of the total childhood mortality. The prevalence of asthma and allergy in children has increased. Prevalence figures vary in different countries, but up to 20 % of children report recurrent wheezing. In some, wheezing is a childhood-limited problem, but others have persistent life-long asthma [2]
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