Abstract
Objectives: The effect of oxytocin on spontaneous electrical activities of rhythmogenic areas in the right and left uterine horns (ovarian and cervical areas) was investigated in non-pregnant rats. Materials and Methods: Comparative analysis of the main characteristics of spontaneous activity (amplitude of action potentials [A]; mean rise- rate [V]; rise - time [T/2]; half-width [t] of spikes; total duration of bursts in 1 minute [D], and spike generation frequency [F]) was conducted. Morphofunctional properties of the rat uterine horns were studied by using a histochemical method, which had been developed based on the Homori method. Results: The left ovarian horn area is characterized by parameters significantly exceeding those of the other three areas, which are identical to each other. Administration of oxytocin, as a factor promoting increased excitability of the myometrium, led to significant enhancement of rhythmogenesis in the right ovarian horn area. Morphohistochemical results revealed an increase in enzymatic activity of the myometrium under the influence of oxytocin, with the right ovarian horn area showing the greatest changes. Conclusion: Since oxytocin plays a key role in stimulating activity and enhancing the myometrial contractions of the right fallopian tube, the possibility of additional reserve capabilities in the regulation of the integrative function of the reproductive organs cannot be excluded from the study.
Published Version
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