Abstract
Neurodegenerative diseases such as Alzheimer’s disease (AD), Parkinson’s disease (PD), amyotrophic lateral sclerosis (ALS), and multiple sclerosis (MS) are worldwide health and economic problems related to increased life expectancy. The exact cause of the etiology of these disorders is not known. Neurodegenerative diseases are of multifactorial etiology, including the role of epigenetic and environmental factors. It has been proposed that oxidative stress–related damage of several macromolecules plays a key role in their pathogenesis. Here, we want to revise the current knowledge regarding the role of reactive oxygen species (ROS) and oxidative stress in neurodegeneration occurring in neurological diseases such as AD, PD, ALS, and MS.
Published Version
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