Abstract
Cushing disease is characterized by the hypersecretion of adrenocorticotropic hormone (ACTH) due to a pituitary adenoma that causes endogenous hypercortisolism by stimulating adrenal glands. Objective of the study was to analyse the benefits of the physical therapy for patients with ACTH-secreting adenomas osteoporosis.This retrospective study was performed at Craiova, Bunavestire Hospital, the patients were monitorized during 6 months and included 17 patients with ACTH-secretingadenomas. Participants in this study group exercised 3 days a week for 6 consecutive months. Each session is intended to take approximately 60 minutes to complete and will comprise of a warm-up, progressive resistance training using medium weights, moderate impact weight-bearing exercises, flexibility and also stretching exercises. Physical therapy for osteoporosis treatment in patients with ACTH-secreting adenomas improved joint mobility and reduced pain, significantly increasing BMD performed by DEXA in group I patients compared to patients included in group II. Pain relief is evident following evaluation using the VAS rating scale. The increase in joint mobility is observed following the goniometric measurement from day 1 to the end of treatment. Applying the physical therapy program the bone pain and joint mobility was improved, physical therapy can modify bone turnover in the sense of increasing the body mass.
Highlights
Cushing’s disease is considered a rare condition characterized by the hypersecretion of the adrenocorticotropic hormone (ACTH) due to a pituitary adenoma that causes endogenous hypercortisolism by stimulating the adrenal glands
It is well accepted that the incidence of Cushing disease is higher among women than among men, with new cases diagnosed at the ratio of 3–8 : 1[7], but in this study we registered 11 women and 6 men with ACTH secreting adenomas
As for the 17 patients diagnosed with Cushing disease there has been performed serum ACTH dosing and as a result there were higher values than the upper limit
Summary
This retrospective study was performed at Craiova, Bunavestire Hospital, the patients were monitorized during 6 months. The present study includes 17 patients with Cushing disease who have muscular and joint pain were divided in 2 groups:. -group I - 9 patients with Cushing disease diagnosed with secondary osteoporosis receiving analgesic and antiresorptive medication as well as physical therapy programme;. -group II - included 8 patients with same characteristics as group I, which didn’t received the physical therapy programme. The physical therapy treatment improve the posture and the alignment of the body segments, ameliorate balance and coordination, increasing the strength and the muscle resistance and joint mobility. Participants in this study group exercised 3 days a week for 6 consecutive months. Each session is intended to take approximately 60 minutes to complete and will comprise of a warm-up, progressive resistance training using free weights, moderate impact weight-bearing exercises, flexibility and stretching exercises
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