The role of neutrophil/ lymphocyte ratio (NLR) with ca 125 in preoperative prediction of malignancy in adnexial mass

Abstract

It is aimed to evaluate the neutrophil / lymphocyte ratio (NLR) and platelet / lymphocyte ratio (PLR) values with CA 125 value in order to distinguish benign / malign / borderline tumors in patients undergoing surgery for adnexal mass. In this retrospective study were included 290 randomized patients having adnexal mass. According to the results of postoperative pathology, 227 patients were benign and 63 were malign. Hematological parameters such as NLR, mean platelet volume (MPV), and PLR were measured in the preoperative period. Multivariate regression analysis was performed statistically to determine the association with CA 125 and hematologic parameters of malignancy in adnexal masses. Women with malignant adnexal mass were older than the ones having benign adnexal mass. CA 125, NLR and PLR levels were statistically higher in patients having malignant adnexal mass than the ones having benign adnexal mass. Age, CA 125 and NLR were associated with malignancy in women with adnexal mass. Multivariable logistic regression analysis depicted that age, CA 125 and NLR were related to increased malignancy risk in adnexal mass (OR=1.047, 95 %Cl =1.023-1.071, OR=1.007, 95 %Cl = 1.004-1.010 and OR=1.228, 95 %Cl = 1.032-1.460, respectively). CA 125, NLR and PLR were positively correlated to malignancy in women with adnexal mass. The CA125 value alone is insufficient for malignancy discrimination. Combination of it with age, and NLR may be useful in distinguishing malignant masses from benign ones in the preoperative period.