After obstructive sleep apnea syndrome surgery, preoperative, postoperative early and late change of neutrophil / lymphocyte ratio, platelet / lymphocyte ratio and mean platelet volume

Abstract

Aim: The aim of this study was to investigate the relationship between the severity of obstructive sleep apnea syndrome (OSAS), neutrophil lymphocyte ratio (NLR), platelet lymphocyte ratio (PLR) and mean platelet volume (MPV), preoperative and postoperative early and late levels of these patients surgery related changes were investigated. Methods: A total of 148 patients (22 women, 14.9% and 126 men, 85.1%) who underwent OSA diagnosis and surgical treatment were included in the study. Patients with mild to moderate OSAS [86 (58.1%)], and severe OSAS [62 (41.9%)] patients with apnea hypoapnea index. (OSAS: 5-15 mild OSAS, AHI: 15-30, severe OSAS AHİ 30>) Patients were divided into two groups. Retrospectively, the blood results of these patients were investigated and preoperative, postoperative early and late full blood results were examined. Results: Weight and BMI values were found to be high in the heavy OSAS group. There was no significant difference between mild-moderate OSAS and severe OSAS groups, preoperative, early and late postoperative periods, and between NLR, PLR and MPV values. Intra-group comparison showed an increase in NLR and PLR in the early postoperative period in both groups. There was no difference between the other values. In late postoperative period, NLR levels decreased to preoperative values while PLR levels were higher than preoperative values. Conclusion: The similarity of NLR, PLR, and MPV values between the mild-moderate and severe OSAS groups as a marker of systemic inflammation and the fact that airway obstruction was remained unchanged suggests that oxidative stress and systemic inflammation in this disease are due to a variety of factors besides airway obstruction.