Abstract
The present study was carried out to relate the role of natural products in the metabolism of an increasingly prevalent disease, type 2 diabetes mellitus. At present, in addition to the pharmacological resources, an attempt is being made to treat diabetes mellitus with natural products. We carried out a systematic review of studies focusing on the role of natural products on diabetes mellitus treatment. The bibliographic search was done through Medline (Pubmed) and Web of Science. From 193 records, the title and summary of each were examined according to the criteria and whether they met the selection criteria. A total of 15 articles were included; after reviewing the literature, it is apparent that the concept of natural products is ambiguous as no clear boundary has been established between what is natural and what is synthetic, therefore we feel that a more explicit definition of the concept of “natural product” is needed. Gut microbiota is a promising therapeutic target in the treatment of diabetes. Therefore, it would be necessary to work on the relationship between the microbiome and the benefits in the treatment of diabetes mellitus. Treatment based solely on these natural products is not currently recommended as more studies are needed.
Highlights
The rapid development of society over the 21st century has brought about a complete change in lifestyle of the population in both a positive and negative way; new risk factors have emerged that have conditioned an increase in the prevalence of chronic diseases worldwide, such as type 2 diabetes mellitus (T2D), which in turn increases the morbidity and mortality of the world population [1]
Annual healthcare costs are calculated to be between 121.97–141.6 million euros, which is why it is estimated that people with T2D generate twice the healthcare costs of persons who do not suffer from this pathology
Changes in fasting plasma glucose and plasma glucose profile and insulin doses were similar in both groups
Summary
Type 2 diabetes is a multifactorial metabolic pathology. It is estimated that eight out of every 1000 inhabitants suffer from it and its prevalence increases in the elderly; it is becoming increasingly common in children and adolescents [2]. Annual healthcare costs are calculated to be between 121.97–141.6 million euros, which is why it is estimated that people with T2D generate twice the healthcare costs of persons who do not suffer from this pathology. Type 2 diabetes is currently deemed one of the pandemics of the 21st century [1,2]
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