Abstract
Cervical cancer (CC) with early metastasis of the primary tumor results in poor prognosis and poor therapeutic outcomes. MicroRNAs (miRNAs) are small, noncoding RNA molecules that play a substantial role in regulating gene expression post-transcriptionally and influence the development and progression of tumors. Numerous studies have discovered that miRNAs play significant roles in the invasion and metastasis of CC by affecting specific pathways, including Notch, Wnt/β-catenin, and phosphoinositide-3 kinase (PI3K)-Akt pathways. miRNAs also effectively modulate the process of epithelial–mesenchymal transition. Many studies provide new insights into the role of miRNAs and the pathogenesis of metastatic CC. In this review, we will offer an overview and update of our present understanding of the potential roles of miRNAs in metastatic CC.
Highlights
Cervical cancer (CC) is one of the most commonly diagnosed cancers and is the third leading cause of cancer mortality amongst females [1]
Despite advances in surgery combined with radiotherapy and/or chemotherapy, some CC patients undergo early metastases of the primary tumor, especially lymph node metastasis (LNM), that lead to poor prognosis and poor therapeutic outcomes [7,8,9,10]
Overexpressed miR-20a [31], miR-21 [168], miR-92a [118], miR-145 [79], miR-195 [166], miR-199b-5p [169], and Conclusion miRNA-based cancer therapy is a relatively new concept, and emerging studies are starting to show the potential roles of miRNAs in the possible clinical therapy for human malignancies. miRNAs have been found to play an important role in the metastasis of cancers such as breast cancer [170,171]
Summary
Cervical cancer (CC) is one of the most commonly diagnosed cancers and is the third leading cause of cancer mortality amongst females [1].
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