Abstract
Purpose: Osteoarthritis (OA) is the most common joint disease. The important risk factors are aging, obese, inflammation and trauma, and these factors impair homeostatic balance through dysregulation of gene expression network in several joint cells including chondrocytes. MicroRNAs (miRNA) play critical roles in multiple processes of development and diseases through control of gene expression. Many studies have shown that miR-140 is an important miRNA in cartilage development and homeostasis. However, there are few reports of other miRNA related with OA pathogenesis using mouse model.
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