Abstract
Epigenetics plays an important role in the pathogenesis and treatment of osteoarthritis (OA). In recent decades, HDAC family members have been associated with OA. This paper aims to describe the different role of HDACs in the pathogenesis of OA through interaction with microRNAs and the regulation of relevant signaling pathways. We found that HDACs are involved in cartilage and chondrocyte development but also play a crucial role in OA. However, the distinct HDAC mechanism in the pathogenesis and treatment of OA require further investigation. Furthermore, HDAC inhibitors (HDACi) can protect cartilage from disease, which may represent a potential therapeutic approach against OA.
Highlights
Osteoarthritis (OA) is a common disease that causes physical disability and imposes an economic burden on society (Litwic et al, 2013; Liu et al, 2018)
This review focuses on the following insights: (1) the relationship between each histone deacetylases (HDACs) and OA; (2) the relevant mechanisms governing HDACs involvement in OA; (3) the potential of HDAC inhibitors (HDACi) in OA treatment
Previous studies demonstrated that HDACs regulate chondrocyte maturation and hypertrophy and protect cartilage from damage
Summary
Osteoarthritis (OA) is a common disease that causes physical disability and imposes an economic burden on society (Litwic et al, 2013; Liu et al, 2018). Due to the aging population and the rising rate of obesity, the prevalence of OA is predicted to double by 2020 (Thomas et al, 2017)
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