Abstract
During the last 30 years, automation of chemical analysis in clinical chemistry has reduced the quantity of blood serum consumed per analysis from approximately one milliliter to a few microliters. Particularly during the last 15 years, this has been the result of improved designs of automated, high-throughput serum analyzers. One consideration in the design changes has been a need to reduce costs by minimizing reagent consumption. In hematology laboratories, automated microchemical analysis of individual blood cells is replacing manual methods of counting white blood cells. Refined methods of cell analysis are coming into use, which give clinically important information that has not heretofore been available to physicians.
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