THE ROLE OF MELATONIN IN COMPLICATED PREGNANCY

Abstract

In recent years, there have been signifi cant changes in the understanding of the hormone melatonin (MT). It has been confi rmed that the processes of conception, pregnancy, and childbirth directly depend on the rhythm and level of MT secretion, but there is no general concept that could describe in detail the mechanisms of infl uence on ontogenesis. The aim of the study. To assess MT in the blood of pregnant with retrochorial hematoma (RCH) up to 12 weeks of pregnancy.Material and methods. Two groups were formed: 1st – 40 pregnant women with RCH, 2nd control– 44 healthy pregnant. Obstetric research, enzyme immunoassay to determine MT, and ultrasound were performed. Statistical analysis according to generally accepted methods of variational statistics.The approval of the scientifi c work was obtained from the Bioethical Commission of the Bukovinian State Medical University (Ukraine).Research results. A signifi cant decrease of MT in the 1st group and the dependence of its level on the size of the RCH was revealed: in the case of hematomas up to 1 cm MT (59.31±10.32 pg/ml) (р ˂ 0.001), which is not observed in hematomas more than 1 cm, which are dangerous for pregnancy (93.98±14.52 pg/ml), which may indicate a compensatory increase in MT; and the term of pregnancy (in 10-12 weeks 79.03±9.61 pg/ml (р ˂ 0.05), in 5-6 weeks 93.78±17.44 pg/ml).Conclusions. In cases of RCH up to 1 cm the number of MT decreases with the development of pregnancy, which can be used as a prognostic marker for the diagnosis of pregnancy complications. The increase in the level of MT with RCH more than 1 cm can be considered as a compensatory increase for the preservation of pregnancy and a regulatory infl uence on the further course of pregnancy.