Abstract
Background Polycystic Ovary Syndrome (PCOS) is one of the most common endocrine abnormalities in women. Due to the side effects of drugs, the tendency to use natural antioxidants and anti-inflammatory agents to regulate metabolism, hyperinsulinemia, and hyperlipidemia in PCOS patients has been increased. This review aimed to investigate the role of herbal substances on the treatment of PCOS. Methods The present review was carried out using keywords such as polycystic ovary syndrome and/or PCOS and/or herb. Databases including Web of Science, PubMed, and Science Direct were used to collect all related articles published from 1990 to 2019. We excluded studies unrelated to the PCOS and medical herbs. Results Overall, 361 records were identified through database searching. After primary screening and the full-texts assessment, 323 records were excluded, and 38 articles were finally included. The results indicate that some medicinal herbs may have a key role in treating PCOS. The compounds in these medical herbs can affect lipid profiles (Aloe vera, chamomile, and cinnamon), insulin resistance (cinnamon, chamomile, Aloe vera, and Camellia sinensis), blood glucose (Aloe vera, cinnamon, and Camellia sinensis), hormones (Aloe vera, silymarin, chamomile, fenugreek, Camellia sinensis, Heracleum persicum, Potentilla, Mentha spicata, Foeniculum vulgar, licorice, and Marrubium), and ovarian tissue (Aloe vera, chamomile, Camellia sinensis, Mentha spicata, and silymarin). Conclusion Natural substances such as Aloe vera, cinnamon, green tea, fenugreek, and silymarin can be used as a new supportive care for PCOS. Further clinical trials are warranted to confirm their benefits and safety.
Highlights
IntroductionPolycystic ovary syndrome (PCOS) is an endocrine disorder related to elevated androgens (male hormones) in females in reproductive age
Polycystic ovary syndrome (PCOS) is an endocrine disorder related to elevated androgens in females in reproductive age
Natural substances such as Aloe vera, cinnamon, green tea, fenugreek, and silymarin can be used as a new supportive care for Polycystic Ovary Syndrome (PCOS)
Summary
Polycystic ovary syndrome (PCOS) is an endocrine disorder related to elevated androgens (male hormones) in females in reproductive age. PCOS is associated with various clinical symptoms such as irregular menstruation, infertility, androgen growth, hirsutism, insulin resistance, acne, weight gain, and ovarian cyst [1]. Some factors appear to play an important in PCOS development including hypothalamicpituitary dysfunction, ovarian dysfunction, and increased insulin level [3]. PCOS is a disorder characterized by abnormal gonadotropin secretion including Luteinizing hormone (LH) and Follicle-stimulating hormone (FSH), and increased secretion of ovarian steroids that may be associated with insulin resistance [4]. The ovaries produce too much testosterone androstenedione and dehydroepiandrosterone in PCOS patients [3, 4]. Polycystic Ovary Syndrome (PCOS) is one of the most common endocrine abnormalities in women. This review aimed to investigate the role of herbal substances on the treatment of PCOS
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