Abstract
To study the correlation between urinary tryptophan metabolites and etiology of bladder tumor, an excretion of urinary tryptophan metabolites (kynurenine and 3-hydroxy-kynurenine: abbreviated as kyn. comp.) before and after a 3gm load of L-tryptophan was measured among the male patients with spontaneous bladder tumor (28 cases), occupational bladder tumor (12 cases), dyestuff worker (9 cases), and for the control normal healthy subjects (41 cases: 22 males, 17 females).The results were:1) In 41 control subjects, pre-loading values were low in both sexes and sexual differences were negligible. However, since the post-loading values among the female subjects were high especially with those who were at the immediate post menstrual stage, only male subjects were used as controls.2) In those patients who had spontaneous bladder tumor, occupational bladder tumor, and dyestuff workers, both pre- and post-loading values were high compared to the control values. These values were statistically significant by Student t test, though their increased values (post-loading value minus per-loading value) were statistically insignificant.3) Post-loading plasma tryptophan values of spontaneous bladder tumor patients were slightly lower than that of control subjects. The values of plasma kyn. comp, were so low that exact measurement of this value was impossible in general.4) Differences in urinary levels of kyn. comp. following the diet containing 3gm of L-tryptophan compared to those following the diet containing 1gm of L-tryptophan were insignificant.
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