Abstract
The role of imbalance between urinary hexanoyl-lysine and total antioxidant capacity levels and its relation to plasma superoxide dismutase levels in autism spectrum disorder
Highlights
The imbalance between oxidants and antioxidants contributes to the pathophysiology of autism spectrum disorders (ASD)
A critical imbalance between the urinary HEL and total antioxidant capacity (TAC) levels may contribute to impaired social responsiveness in individuals with ASD without the DNA methylation
The Social Responsiveness Scale (SRS) subscale and total scores being used as the dependent variables, the statistical significance of contribution of the SRS subscale of awareness to the urinary HL levels. These findings indicate that urinary levels of TAC and HEL were predictable measures for differences in the biomarkers and the SRS scores between the ASD group and the control group (Table 2)
Summary
The imbalance between oxidants and antioxidants contributes to the pathophysiology of ASD. ASD symptoms usually appear during early development and generally lead to serious lifelong limitations in function; both genetic and environmental factors may contribute to its development [2,3]. Regulation of reduction/oxidation (redox) state is important for cell viability, proliferation and organ function [4], imbalance of oxidant/antioxidant balance such as overproduction of ROS became toxic to neurons, inducing DNA methylation [5] and various tissues damage [6]. Because the brain is highly vulnerable to oxidative stress during early development [6], oxidative stress-induced neuronal damage may occur in genetically predisposed individuals [7]. Deficits in antioxidant capacity may important in the etiology of ASD. The total antioxidant capacity (TAC) in urine and plasma is a parameter used to characterize the antioxidant status of the body [8,9]
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