Abstract
Impact of endocrine disruptors on sexuality: a pediatric aspect
Highlights
Endocrine disruptors(EDs) can act and disturb the function of endocrine system during the whole life their impact is outstanding during childhood, as the effects in this period could lifelong influence different processes, mainly in the sexual area
The above mentoned data clearly show that the endocrine disruptors strongly influence the sexuality in man and in animal experiments
There is a possibility of direct effects, when the hormonal exposure is teratogenic, which is manifested first of all in cryptorchidism or hypospadias or micropenis an other possibility is the late effect, when the perinatal exposure does not provoke malformation later, during adolescence or in adult age pathological alterations appear, as early onset of puberty, obesity or changes in sexual capacity and behavior
Summary
As the fetus is living in the womb, mostly maternal hormones are regulating its life functions. Though the binding of receptor is almost specific for the hormone, perinatally it can be misdirected by hormone analogons [22], related or synthetic hormones, members of a hormone family , hormone-like vitamins [23,24], drugs, or environmental pollutants, as the endocrine disruptors This leads to faulty hormonal imprinting, the effect of which is prolonged for life and could cause differences in hormone binding and sexual hormone levels [25], inclination to diseases or manifest diseases (e.g. tumours). The faulty imprinting effect of this fungicide was manifested transgenerationally when male infertility was observed [40].The phytoestrogen, genistein given perinatally negatively influenced sperm and testosterone production and aggressivity decreased while defensive reactions increased in adult age [41]. Higher serum testosterone concentrations were associated with higher phtalate and BPA concentrations in maternal urine during different phases of pregnacy [71]
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