The Role of IL-23 in Patients with Idiopathic Thrombocytopenic Purpura

Abstract

Idiopathic thrombocytopenic purpura (ITP)is a bleeding disorder with an unclear etiology ,The most common hemorrhagic autoimmune disease, and characterized by isolated thrombocytopenia that is not accompanied by any other disorders that may lead to thrombocytopenia. Interleukin-23 (IL-23) is a member of the IL-12 family; it is primarily secreted by activated dendritic cells, Monocytes, and macrophages and has important implication in the pathogenesis of many autoimmune diseases. The aims of this study was to evaluate the role of IL-23 in diagnosis of idiopathic thrombocytopenic purpura. A total of 5 papers were obtained using the mentioned keywords in the research of all internet-based databases. The total number of cases in all of the studies was 239 cases. The mean age was recorded in 5 papers, and the mean age of each of them was 32.8 years. There are different method of detection of IL23 in different studies such as PCR, ELISA and flow cytometry These findings suggest that levels of IL-23 are significantly higher in ITP patients.