Diagnosis and prognosis analysis of platelet antibodies and serum interleukin in patients with idiopathic thrombocytopenic purpura

Abstract

Objective To explore the application value of platelet antibodies (PAIgG, PAIgA, and PAIgM) and serum interleukins (IL-6, IL-17, and IL-18) in the diagnosis and prognosis of idiopathic thrombocytopenic purpura(ITP). Methods A total of 125 ITP patients admitted to the our department from March, 2014 to December, 2017 were selected as study objects; and 50 healthy examinees were selected as a control group. The serum levels of PAIgG, PAIgA, PAIgM, IL-6, IL-17, IL-18, and platelet(PLT) were measured in each group; and the differences between these groups were analyzed. The clinical efficacy of ITP was followed up. The differences of the above indicators after treatment were evaluated. Results The serum levels of PAIgG, PAIgA, PAIgM, IL-6, IL-17, and IL-18 were all higher and the PLT count was lower in the acute ITP group and the chronic ITP group than in the control group (all P<0.05). Pearson correlation analysis showed that IL-6, IL-17, IL-18, PAIgG, PAIgA, and PAIgM were positively correlated with PLT (r=0.215-0.508, P<0.05), and that IL-6, IL-17, IL-18, PAIgG, PAIgA, and PAIgM were negatively correlated with PLT (r=-0.295~-0.417, P<0.05). The serum levels of PAIgG, PAIgA, PAIgM, IL-6, IL-17, and IL-18 in patients with ITP in the response group were lower than those in the non-response group (P<0.05) . The area under curve (AUC) of the diagnosis of ITP by platelet antibody combined with interleukin was 0.922 (95% CI: 0.853-0.991, P<0.05), and the AUC predicting the efficacy of ITP was 0.830 (95% CI: 0.729~0.931, P<0.05). Conclusion The levels of platelet antibodies and interleukins in ITP patients is significantly increased, which is related to PLT count and ITP treatment effect. The combination of platelet antibody and interleukin is of high value in diagnosing ITP and judging ITP efficacy. They can be used as effective serological indicators in the diagnosis and prognosis of ITP. Key words: Platelet antibody; Lnterleukin; Idiopathic thrombocytopenic purpura; Diagnosis; Prognosis