Abstract
The activity of hyaluronidase which was detected in the urine of man and animals in weak diuresis is changed according to a characteristic curve when urine excretion is increased. Dependence of its activity on the diuresis cannot be explained by dilution, salt effect or by the change of the volume of urine in which the enzyme is distributed. Evidently the curve of hyaluronidase activity is connected with varying intensity of liberation of the enzyme by the elements of kidney tissue. High hyaluronidase activity is found in cases when the concentration of the antidiuretic hormone in the blood is high and intense reabsorption of water takes place in the distal segment of the nephron. This suggests that excretion of hyaluronidase by the elements of kidney tissue has a direct relationship to the process of active reabsorption of water. It is regulated by the antidiuretic hypophyseal hormone.
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