Abstract
The Role of Histamine and Serotonin in the Control of Vascular Motricity of the Anterior Ocular Segment - Review of the Literature from 1997 to 2018
Highlights
Histamine and serotonin, besides known systemic effects, can influence vascular tone at the eye level
Serotonin (5-HT), synthesized from the tryptophan, exhibits vascular effects, which began to be studied a few years after its discovery[5]
This paper aims to evaluate the influence of histamine, serotonin and related substances acting on histamine and serotonin receptors upon anterior ocular vascularisation by studying the literature from 1997-2018
Summary
Besides known systemic effects, can influence vascular tone at the eye level. Specific agonists or antagonists acting in the histamine and serotonin domains, are probably more useful than endogenous substances as working tools for discovering the functional elements involved in regulating ocular vascular tone. Knowing that intraocular pressure regulation depends on the vascular tone of the anterior ocular segment, some of the substances under review may be candidates for potential intraocular pressure lowering drugs. Substanţele care modulează la nivel de receptor aceste efecte (agoniștii și antagoniștii histaminergici și serotoninergici) sunt probabil mai utili decât substanţele endogene ca instrumente de lucru pentru descoperirea elementelor funcţionale implicate în reglarea tonusului vascular ocular. Several reviews about the cardiovascular effects of serotonin[6] have been published
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