The Role of Glutathione Administration in the Treatment of Infertility Men

Abstract

Lipid peroxidation negatively affects sperm function by decreasing the number of motile sperm in the reproductive tract, which is caused by a disruption in the balance of sex hormones that regulate male fertility. A total of 80 adult men, aged 36-55 years, participated in this study. The group comprised 40 fertile control men and 40 men with idiopathic infertility who received antioxidant treatment. Among them, 15 men were younger than 36 years and 65 men were older than 36 years. All the infertile men had been married for at least five years and had no children. The study samples were collected from an infertility clinic at Kirkuk Teaching Hospital and private clinics. Each patient received glutathione supplementation once a day for five months, starting oral antioxidant therapy in July and continuing until December 2023, along with garlic taken twice daily with food. Initially, there were slight but significant differences observed in FSH and LH levels between the control group and infertility patients before treatment, while testosterone levels were significantly lower in the infertility group. However, after five months of treatment, there was a significant increase in FSH, LH, and testosterone levels in the idiopathic infertility group compared to the control group. The research indicated a significant increase in seminal plasma glutathione (GSH) and glutathione peroxidase (GPx) and a significant reduction in seminal plasma malondialdehyde (MDA). These changes led to a significant increase in the sperm count of idiopathic infertility men after five months of treatment compared to the control group. Furthermore, FSH levels significantly increased after two months of treatment, with a corresponding increase in serum GSH. Thus, the administration of glutathione with garlic significantly reduced serum MDA and significantly increased serum FSH, total testosterone, and the count of motile sperm in idiopathic infertility men. Key Words: L-Glutathione250MG , Garlic ,idiopathic infertility men ,sperm count ,total testosterone