Abstract
Objective: The interactions between Helicobacter pylori (Hp) and gastroesophageal reflux disease (GERD) are a complex issue. The aim of this study was to investigate the correlation between Hp infection and the gastric localization of Hp and reflux esophagitis (RE) in adult patients. Material and Method: Two hundred thirty-nine patients with RE were compared with 229 age and sex matched participants in a control group. Biopsy specimens obtained from the gastric antrum and corpus were histologically evaluated. Results: The prevalence of Hp infection was significantly lower in the patients with RE than in the control group (Odds ratio 1.56, 95% CI 1.08-2.27; p=0.02, p<0.05). Hp colonization in the corpus and gastrit scores in the corpus were significantly lower in the esophagitis group (p=0.01, p<0.05), but there was no significant difference in Hp colonization in the antrum and gastrit scores in the antrum. It was found that Hp colonization and gastrit score in the corpus showed a negative correlation with esophagitis development. Conclusion: This study demonstrated that the prevalence of Hp infection and corpus gastritis score were significantly lower in patients with erosive reflux esophagitis than in the control group. Furthermore, it demonstrated that Hp colonization and corpus gastritis score were negatively correlated with esophagitis development.
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