Abstract
Atherosclerosis is the pivotal role of cardiovascular disease (CVD) involving oxidative stress dan inflammation. Garcinia has anti-oxidant property for years. This study was performed to explore the role of α-Mangostin of Garcia Mangostana Pericarp Extract as an antioxidant in inhibiting atherosclerotic process in patients with high-risk Framingham score. Methods: This prospective cohort design was led in 90 grown-ups with high hazard cardiovascular score which were resolved dependent on Framingham criteria, age 50–70 years of age. The patients were divided into two groups. One group was administered 2520 mg/day Garcinia mangostana Linn extracts (GMLE) in 3 divided doses for 90 days and the other group was administered a placebo. Parameters were Nitric Oxide (NO), Superoxide Dismutase (SOD) and Malondialdehyde (MDA), measured at baseline and after 90 days of treatment. An Independent T-test was performed for normally distributed data and the Mann-Whitney test was performed for abnormally distributed data with a significance level of p≤0.05. Results: Among the 77 subjects, we found that the plasma, MDA, concentration was significantly decreased compared with placebo 0,29±0.5 vs -0.04±0.25, respectively p = 0.011). SOD level significantly decreased in GMLE patients compared with placebo patients (0,17±0.79 vs -0.27±0.67, respectively, p=0.010) and we found that there was slightly increased in nitric oxide (NO), but no significantly compared with placebo 4.34±10.01 and 2.35±7.39, respectively, p = 0.37). Conclusion: Garcinia mangostana pericarp extract has an antioxidant effect that significantly inhibit atherosclerosis process in high-risk Framingham score patients
Highlights
Cardiovascular disease (CVD) is a general term for heart and blood vessel disease.[1]
Cardiovascular disease is the primary cause of death worldwide, with more than 17.3 million death annually in 2013, and predicted to grow more than 23.6 million in 2030.2 Among them, 7.4 million death were estimated caused by coronary heart disease and 6.7 million by stroke.[3]
Blood samples were obtained from patients before and after received GMLE and placebo for 90 days
Summary
Cardiovascular disease (CVD) is a general term for heart and blood vessel disease.[1]. Objectives : This study was performed to explore the role of α-Mangostin of Garcia Mangostana Pericarp Extract as an antioxidant to inhibit atherosclerotic process in patients with high-risk Framingham score. The outcome measures in our study were Nitric Oxide (NO), Superoxide Dismutase (SOD), and Malondialdehyde (MDA). They were measured at baseline and 90 days after treatment. SOD level significantly decreased in GMLE patients compared with placebo (0,17±0.79 vs -0.27±0.67, respectively, p=0.010) and we found that there was slightly increased of nitric oxide (NO), but no significantly compared with placebo 4.34±10.01 and 2.35±7.39, respectively, p = 0.37). Conclusion: Garcinia mangostana pericarp extract has an antioxidant effect that significantly inhibits atherosclerosis process in high-risk Framingham score patients
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