Abstract
Hypertrophic cardiomyopathy (HCM) is a common genetic disorder characterized by myofibrillar hypertrophy, disarray and myocardial fibrosis, with a population prevalence of 1 in 500. Cardiac magnetic resonance imaging (CMR) has evolved as an increasingly important investigation in the diagnosis and management of patients with HCM. CMR provides very high spatial (0.5 mm) and temporal resolution cine images, which facilitate accurate and reproducible assessment of the left ventricular function; peak left ventricular wall thickness and quantification of the burden of fibrosis [ [1] Weng Zhen et al. Prognostic value of LGE-CMR in HCM. J. Am. Coll. Cardiol. Img. 2016; 9: 1392-1402 Crossref Scopus (241) Google Scholar ]. These factors all aid in the diagnosis and management of HCM. Prognostic implications of global myocardial mechanics in hypertrophic cardiomyopathy by cardiovascular magnetic resonance feature tracking. Relations to left ventricular hypertrophy and fibrosisInternational Journal of CardiologyVol. 249PreviewInterstitial fibrosis, myocardial fiber disarray and non-uniform shortening are common histological features of hypertrophic cardiomyopathy (HCM). The degree of LV hypertrophy and fibrosis are postulated to contribute to the impairment of myocardial shortening. Cardiovascular magnetic resonance myocardial (CMR) feature tracking (CMR-FT) has emerged as a robust method that provides quantitative measurements of myocardial deformation. Our aim was first to evaluate LV strain parameters in HCM by CMR-FT and their dependence on both functional parameters and late gadolinium enhancement (LGE); and secondly we sought to determine their association with major cardiovascular outcomes. Full-Text PDF
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