Abstract
Obesity-associated hyperlipidemia is a major risk factor for cardiovascular diseases, metabolic syndrome, and other complications. The dysregulation of lipid metabolism in obesity is driven by a complex network of molecular and cellular mechanisms. Among these, exosomal microRNAs (miRNAs) have emerged as key regulators in the communication between adipose tissue, the liver, and other metabolic organs. Exosomes, small vesicles secreted by various cell types, contain miRNAs that can modulate gene expression in recipient cells, thereby influencing lipid metabolism. This review explores the role of exosomal miRNAs in obesity-associated hyperlipidemia, focusing on their mechanisms of action, regulatory functions, and potential therapeutic implications. We highlight specific exosomal miRNAs involved in lipid metabolism pathways, their role in adipogenesis, lipogenesis, and lipid storage, as well as their impact on systemic lipid homeostasis. Additionally, we discuss the potential of targeting exosomal miRNAs as a novel therapeutic approach for managing hyperlipidemia and obesity-related metabolic disorders. Keywords: exosomal miRNAs, lipid metabolism, obesity, hyperlipidemia, adipogenesis, lipogenesis, therapeutic targeting
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