Abstract
Mutants of bacteriophage λ ( red −) that are defective in general recombination have been classified according to their behavior in complementation (Shulman, Hallick, Echols & Signer, 1970). Mutants in the red B complementation group often affect the production of β protein and sometimes affect exonuclease also. One mutant affects the immunologic properties of β protein. Thus these mutants identify the probable structural gene for β protein. Mutants of red A and red C affect exonuclease, two of the latter producing inactive exonuclease that is immunologically detectable (CRM). Exonuclease made by one pair of complementing A and C mutants is thermolabile, consistent with the hypothesis that the A and C complementation classes are part of the same gene. The relationships between mutations in the red genes and structural alterations of both exonuclease and β protein suggest that these two proteins are principally involved in genetic recombination.
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