Abstract
The Role of Estradiol in Idiopathic Anterior Uveitis during the Eumenorrheic Stage of Life
Highlights
Non-infectious uveitis is the most common form of uveitis observed in the United States, and approximately 81% of noninfectious uveitis cases were diagnosed as anterior non-infectious uveitis
The incidence and intensity of uveitis flare-up is more pronounced during the active reproductive period of life
Differences in sexual hormone milieu are likely a major factor contributing to the differences in presentation of uveitis amongst eumenorrheic and postmenopausal women
Summary
Non-infectious uveitis is the most common form of uveitis observed in the United States, and approximately 81% of noninfectious uveitis cases were diagnosed as anterior non-infectious uveitis. [2] Many of these disorders are found to be more common in women than men. Brandt el al and Clayton el al reported that 60 to 80% of those affected by autoimmune disorders are women. These autoimmune disorders include rheumatoid arthritis, multiple sclerosis, systemic lupus erythematosus, Graves’ disease, and Hashimoto’s disease. [3, 4] Similar to other autoimmune diseases, women have a higher prevalence of anterior noninfectious uveitis. [1] There is a significant body of literature on the biological differences between men and women that may affect the course of autoimmune disease. Differences in female sex steroid hormones are likely responsible for the dissimilarity in disease course between males and females
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