Abstract
Rosacea is a common skin disease with a chronic recurrent course. Numerous factors of etiology and pathogenesis of this dermatosis, which may influence the appearance of its clinical signs, have not been elucidated. The aim of the work is to determine the content of endogenous neuropeptides (substance P, leu-enkephalin) in the blood, to find out their role in the development of clinical manifestations of rosacea in women. Materials and methods - 47 women with rosacea were clinically and laboratory examined in whom the levels of substance P and leu-enkephalin in the blood were determined by enzyme-linked immunosorbent assay. Results. Quantitative assessment of the degree of manifestations of clinical signs of local redness of the skin and subsequent symptoms of rosacea (pink acne) in women indicates a complex nature of changes in the skin and reactions of the nervous and endocrine systems. The revealed imbalance in the blood of patients with endogenous neuropeptides with different mechanisms of effector and regulatory action (increase - substance P, decrease - leu-enkephalin) indicates a violation of the mutual compensatory relations of these peptide signaling molecules in different functional systems of the body, and the following symptoms of the disease, which differed in women of reproductive and older age.Conclusions. Imbalance of levels of endogenous neuropeptides with opposite effector and regulatory effects (substance P, leu-enkephalin) may be one of the key pathogenetic factors of the appearance and development of clinical manifestations of rosacea in women given the polypotent mechanisms of action of these biologically active compounds as neurotransmitters and antinociceptive mediators, regulators of emotional and behavioral reactions, pro- and anti-inflammatory factors, coordinators of the hypothalamic-pituitary-gonadal system. Misdiagnosis of such manifestations of the disease as rosacea-tides with «menopausal», «migraine-like» and other types of tides in women dictate the need for a comprehensive examination of such patients.Кey words: rosacea, substance P, ley-enkephalin, women’s.
Highlights
Imbalance of levels of endogenous neuropeptides with opposite effector and regulatory effects may be one of the key pathogenetic factors of the appearance and development of clinical manifestations of rosacea in women given the polypotent mechanisms of action of these biologically active compounds as neurotransmitters and antinociceptive mediators, regulators of emotional and behavioral reactions, pro- and anti-inflammatory factors, coordinators of the hypothalamic-pituitary-gonadal system. Misdiagnosis of such manifestations of the disease as rosacea-tides with «menopausal», «migraine-like» and other types of tides in women dictate the need for a comprehensive examination of such patients
Кількісна оцінка ступеня проявів клінічних ознак приливів локального почервоніння шкіри обличчя та наступних симптомів розацеа у жінок свідчить про комплексний характер змін з боку шкіри та реакцій нервово-ендокринної системи
Выявленный у обследованных женщин репродуктивного возраста, больных розацеа, дисбаланс ведущих маркеров противоположно направленных эффектов нейропептидов разных групп (субстанция Р, лей-энкефалин) свидетельствует о необходимости комплексного их обследования для исключения диагностических ошибок на ранних стадиях возникновения дерматоза и своевременного внесения патогенетически обоснованных корректив в системы комплексного лечения, профилактики и реабилитации таких пациенток
Summary
Изучить содержание в периферической крови ноцицептивных (субстанция Р) и антиноцицептивных (бета-эндорфин, лей-энкефалин) эндогенных нейропептидов у женщин, больных розацеа и их роль в развитии клинических проявлений разных стадий заболевания. Все больные женщины первым видимым и ощущаемым признаком, свидетельствовавшим об изменении функционального состояния их кожи лица отмечали внезапное появление приступа «прилива крови» (в дальнейшем: розацеа-приливов) к центральной (чаще – назо-лабиальной) его части, сопровождавшегося покраснением кожи в этой зоне и чувством локального тепла или легкого «жара», что через несколько минут такого приступа бесследно исчезало без всякого лечения.
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