The Role of Dl-Dihydroxy Phenyl Alanine (Dopa) on Plasma Transaminase Level Under Altitude Stress

Abstract

Various conditions of experimental and clinical stress and exercise are followed by a change in the level of transaminases in plasma and tissues. This is also true under various pathological conditions. Andreotti et al. (1) reported a transient increase in serum glutamic-oxalacetic (GOT) and glutamic-pyruvic transaminase (GPT) levels during a boxing match. Lending et al. (2) found that there is no significant effect on plasma GOT levels of puppies when exposed under reduced atmospheric pressure conditions for 3 hr. Bedrak (3) observed that even exposure to heat stress and muscular exercise increased the serum GOT and GPT levels of dogs as compared to the corresponding controls. Nerdrum and Berg (4) reported an increase in serum GOT level 10 min after brief exertion, falling to normal in 45 min. Vanlerenberghe et al. (5) found that rats subjected to hypoxia showed marked increase in serum GOT and GPT levels.