Abstract
Copyright: © 2012 Shimada M. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. During ovulation process, cumulus cells produced and accumulated hyaluronan (HA) rich matrix within cumulus cell layers, called as cumulus expansion. The expanded cumulus oocyte complex is ovulated from follicle, and then fertilized in oviduct. It has been known that the fertilization rate of oocyte in vitro is higher when expanded COCs are used for in vitro fertilization as compared with that in denuded oocyte. However, the positive roles of cumulus cells in fertilization process were remained unclear.
Highlights
During ovulation process, cumulus cells produced and accumulated hyaluronan (HA) rich matrix within cumulus cell layers, called as cumulus expansion
Using mutant mouse models the functional relevance of HA and HA binding proteins has been documented by a wealth of biochemical data and physiological studies
The level of Tnfaip6 mRNA was significantly lower in mice null for either Ptgs2 or Ptger2 than in their wild type littermates [1,2], indicating that Tnfaip6 gene expression was dependent on prostaglandin E2 and its receptor pathway
Summary
Cumulus cells produced and accumulated hyaluronan (HA) rich matrix within cumulus cell layers, called as cumulus expansion. Using mutant mouse models the functional relevance of HA and HA binding proteins has been documented by a wealth of biochemical data and physiological studies.
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