The Role of Chlorhexidine Acetate (CA)-Monotmorillonite (MMT) Nanoparticles in Implantable Venous Access PORT Nursing of Hematopathy Patients

Abstract

This study was intended to explore the effects of Chlorhexidine di(acetate)-Na-Monotmorillonite (CA-MMT) nanoparticles on implantable venous access port (PORT) nursing of hematopathy patients, which was expected to provide a more effective alternative for PORT nursing and alleviate the suffering of hematopathy patients. CA-MMT nanoparticles were prepared and characterized by X-ray and infrared spectroscopy. Specifically, CA and Na-MMT were dissolved in double distilled water, and then added to a round-bottomed flask and mixed uniformly. After the mixture was condensed and refluxed, the product in the flask was filtered, and then washed with double distilled water for several times, followed by suction filtration. The obtained off-white block solid was dried at high temperature, and then ground and sieved to obtain CA-MMT nanoparticles. 64 hematopathy patients were selected as research subjects and were randomly divided into control group and nano group. After the PORT surgery, the nano group had CA-MMT nursing, with the control group having iodophor nursing. The routine blood indexes and the phlebitis incidence were compared between the two groups for analysis. The results showed that the CA was successfully intercalated between layers of MMT, which had a relatively good dispersion property with a regular shape. Before the puncture, the two groups showed no notable differences (P > 0.05), while after the needle was removed, a notable difference was noted (P < 0.05). The phlebitis probability in the control and the nano group was 37.5% and 15.6%, respectively, indicating a notable difference (P < 0.05). In conclusion, the CA is successfully intercalated between MMT layers. The CA-MMT nanoparticle is instrumental in reducing the incidence of infections and phlebitis, demonstrating good effects on PORT nursing of hematopathy patients.