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https://doi.org/10.1016/0014-4886(81)90139-4
Copy DOIJournal: Experimental Neurology | Publication Date: Apr 1, 1981 |
Citations: 79 |
High cervical spinal cord hemisection produces a permanent paralysis of the ipsilateral hemidiaphragm. In many species, function is restored to this paretic hemidiaphragm if the contralateral hemidiaphragm is paralyzed by transecting the phrenic nerve. This response is termed the “crossed phrenic phenomenon.” The present study determines the long-term effects on diaphragmatic function after anesthetization or crushing the contralateral phrenic nerve, or after cutting its dorsal roots in rats subjected to a high cervical spinal cord hemisection. Dorsal root transection was the only procedure which resulted in a partial functional recovery of the hemidiaphragm paralyzed by the spinal cord hemisection without a loss of function in the contralateral hemidiaphragm. The results suggest that afferent nerve fibers in the contralateral phrenic nerve may normally inhibit the functional expression of the crossed phrenic pathway, although the precise mechanism for this inhibition is not yet known.
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