Abstract
Viroplasms, cytoplasmic inclusion bodies in rotavirus (RV)-infected cells in which viral RNA replication and early morphogenesis take place, were found to be associated with the cellular organelles lipid droplets (LDs). Compounds affecting LD homoeostasis, including agents causing lipolysis and others that inhibit fatty acid biosynthesis, decrease RV replication. Gradient ultracentrifugation of infected cell extracts shows LD components cosedimenting with viroplasms in low-density fractions. Disturbance of fatty acid biosynthesis decreases the production of both double-layered and triple-layered (infectious) RV particles. Future studies should explore the LD components important for RV replication, and the potential of chemical compounds interfering with lipid metabolism for treatment of RV disease.
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