Abstract
The review examined of the processes of cell proliferation in human vascular wall and experimental animals during the formation of atherosclerotic plaques. Shows the types of actively proliferating cells: lymphocytes, macrophages, endotheliocytes and zones identified in the vascular wall, where this proliferation occurs. The factors that promote and hinder cell proliferation during the growth of atherosclerotic plaque are identified. The survey shows all the stages of the formation of atherosclerotic lesions, ranging from normal plots and lipid stains to pronounced fibrous plaques. Establishes a link between the cell proliferation and inflammation in the vascular wall man. Separately considered the role of cell proliferation in the destabilization of atherosclerotic plaque. If atherosclerosis this process still poorly studied, in the formation of unstable atherosclerotic plaques in humans it is completely unknown. Based on your own original data was finally on the important role of the processes of cell proliferation in the formation of unstable atherosclerotic plaques in humans.
Highlights
В обзоре представлены процессы клеточной пролиферации в сосудистой стенке человека и экспериментальных животных при формировании атеросклеротической бляшки
The review examined of the processes of cell proliferation in human vascular wall and experimental animals during the formation of atherosclerotic plaques
Shows the types of actively proliferating cells: lymphocytes, macrophages, endotheliocytes and zones identified in the vascular wall, where this proliferation occurs
Summary
Роль клеточной пролиферации в атерогенезе и при дестабилизации атеросклеротической бляшки у человека // Медицинский академический журнал. В обзоре представлены процессы клеточной пролиферации в сосудистой стенке человека и экспериментальных животных при формировании атеросклеротической бляшки. Обсуждается вопрос о роли клеточной пролиферации при дестабилизации атеросклеротической бляшки. На основании собственных данных сделано заключение о важной роли процессов клеточной пролиферации в формировании нестабильной атеросклеротической бляшки у человека. The role of cell proliferation in atherogenesis and in the destabilization of atherosclerotic plaque in human. The review examined of the processes of cell proliferation in human vascular wall and experimental animals during the formation of atherosclerotic plaques. Based on your own original data was on the important role of the processes of cell proliferation in the formation of unstable atherosclerotic plaques in humans. Восканьянц, Список сокращений ГМК — гладкомышечные клетки; ИФР-1 — инсулиноподобный фактор роста; MIR — микроРНК
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