Abstract
BackgroundNon-alcoholic fatty liver disease (NAFLD) is a classic disease of liver injury, and studies have confirmed that nutrients can influence NAFLD. Findings on serum vitamin D (VD) and NAFLD are conflicting and the mechanisms are not yet clear. This study aimed to determine the association between the two and the mediating role mediated by body mass index (BMI). MethodsA cross-sectional study (N = 2609) was conducted using the 2017–2018 National Health and Nutrition Examination Survey (NHANES) dataset. Weighted multivariate logistic regression models estimated OR and 95 % CIs between serum VD and NAFLD. The mediation analysis was performed for BMI. ResultsSerum VD was statistically significant in subjects with and without NAFLD (P = 0.026). Adequate serum VD was found to be a protective factor for NAFLD after adjusting for covariates (OR (95 %CI) of 0.717 (0.553,0.929)). After mediation analysis, it was found that BMI mediated 34.07 % of the effect of serum VD on NAFLD. ConclusionThere is an association between serum vitamin D and NAFLD and sufficient VD was protective factor for NAFLD. BMI partly mediated the association between serum VD and NAFLD.
Published Version
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