The Role of B Cells in Skin Inflammation

Abstract

The role of B cells in skin inflammation highlights the versatility of B cells in their response to diverse immune stimuli perceived as external threats to the host. B cells play a vital role in the immune system’s ability to effectively respond to offenses to the healthy skin microenvironment, such as wounds, malignant tumors, vector (tick)-borne pathogens, and the development of red meat allergies after a tick bite. Select examples from the literature that illustrate the role of B cells in these disrupted states reviewed individually below, and highlight little overlap in the role B cells play in the different diseases. Future studies will need to continue to research the relatively newfound role of B cells in maintaining healthy skin.