Abstract
Chromium (Cr) causes delayed-type hypersensitivity reactions possibly mediated by accumulating T cells into allergic inflamed skin, which are called irritants or allergic contact dermatitis (ICD or ACD). However, accumulating T cells during development of metal allergy are poorly characterized because a suitable animal model is not available. This study aimed to elucidate the skewing of T-cell receptor (TCR) repertoire and cytokine profiles in accumulated T cells in inflamed skin during elucidation of Cr allergy.
Highlights
Metal allergy is categorized as a delayed-type hypersensitivity (DTH) reaction, and may be caused by metal ions released from dental materials, jewelry, and coins [1]
This study demonstrated the successful establishment of a murine model of Cr-induced ICD and allergic contact dermatitis (ACD) with appropriate pathology
We observed that allergen specific T cells used a specific T-cell receptor (TCR) repertoire in Cr-induced ACD mice
Summary
Metal allergy is categorized as a delayed-type hypersensitivity (DTH) reaction, and may be caused by metal ions released from dental materials, jewelry, and coins [1]. The number of patients with metal allergy has increased because metal is increasingly used for jewelry, surgical instruments, and dental restorations [1]. Cr hypersensitivity is one of the major occupational metal skin diseases especially in cement workers [2,3]. Cr hypersensitivity is common in the general population with a prevalence of approximately 0.5% [4,5], whereas the prevalence in cement workers is approximately 4.5% [4,6]. Skin exposure to Cr produces both irritant (ICD) and allergic contact dermatitis (ACD). The irritant reaction does not require previous sensitization, and both types of contact dermatitis, despite their induction by different mechanisms, have not been differentiated by macroscopic appearance [8]
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.