Abstract
Summary Different methods of inducing drug-resistance of T. equiperdum towards p-rosaniline HCl were compared. The “classical” technic of rendering trypanosomes resistant by treatment of relapses with slowly increasing doses of the dyestuff was inferior to methods which avoid the formation of antibodies (short passage; splenectomy). Drug-resistance was more difficult to achieve in rats than in mice, due to more abundant antibody-formation in rats. Splenectomy and short passage combined gave satisfactory results. The rapid development of p-rosaniline-fastness in splenectomized mice was counteracted by passive immunization with trypanocidal rabbit serum.
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