Abstract
Objective: To evaluate in vitro the value of antacids as an alternative to H2 blockers to raise gastric juice pH for reliable PCO2 tonometry in the human stomach. Design and setting: Laboratory study in a university hospital. Interventions: A bath was filled with 0.1 M hydrochloric acid at pH 1.3 and CO2 was gassed through the acid to simulate an intragastric environment. Experiments were performed in duplicate. Both the manual saline technique and the new semi-continuous, semi-automated air technique of PCO2 tonometry were used to evaluate the effects of adding i) aluminium oxide/magnesium hydroxide (Antagel ®) and ii) sodium bicarbonate on the PCO2. The latter technique was done to simulate intragastric CO2 production following buffering of gastric acid by bicarbonate in the mucosa, or in the saliva or pancreatic/duodenal juice entering the stomach, an effect that can be prevented in vivo by prior administration of H2 blockers. Endpoints: Changes in tonometrically determined PCO2 after the addition of a...
Published Version
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