The role of amino acids in the processes of nucleation of pathogenic crystals of calcium oxalate monohydrate under human body imitating conditions

Abstract

The influence of amino acids such as leucine, methionine, and phenylalanine on the kinetics of the nucleation of pathogenic crystals of calcium oxalate monohydrate (COM) was studied. Leucine, methionine, and phenylalanine molecules were found to promote the processes of nucleation and reduce the induction time of pure COM by 2–3 times (the induction time of pure COM – 100 s). The boundary concentration of the amino acids leucine and phenylalanine, above which the amino acids can have a promoting effect on the kinetic parameters of nucleation of COM crystals, was estimated as 1 mM. It was found that Leu and Met amino acid in the concentration range of 1–20 mM do not affect the morphology of COM crystals.