Abstract
The effects of adenosine A2A receptor antagonist microinjections into the hypothalamic ventrolateral preoptic area (VLPA) on the natural sleep-wake cycle and somnogenic activity of a 70 kDa heat shock protein (Hsp70) are analyzed electrophysiologically in birds, specifically, pigeons (Columba livia) for the first time. We report that: (1) at the beginning of the rest period, microinjections of 8-(3-Chlorostyryl)caffeine (ChC), an adenosine A2A receptor antagonist, into VLPA increase wake duration and inhibited sleep in a dose-dependent manner; (2) Hsp70 injections into VLPA evoke the somnogenic effect manifested as an increase in total slow-wave sleep (SWS) duration and enhancement of the mechanisms responsible for SWS triggering and maintenance; (3) ChC blockade of adenosine A2A receptors inhibits Hsp70-induced SWS. These data suggest that adenosine A2A receptors located in VLPA are involved in the modulation of the natural sleep-wake cycle and promotion of the Hsp70 somnogenic effect in pigeons. It is hypothesized that the somnogenic effect of Hsp70 is mediated by the modulating influence of this chaperone on the functioning of adenosine receptor proteins.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
More From: Journal of Evolutionary Biochemistry and Physiology
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.