Abstract

Modern data on the role of vitamin B12, and its biologically active form holotranscobalamin in particular, in the development of anemia of pregnancy are presented. Information on the vitamin B12 metabolism and its coupling with the folic acid and homocysteine metabolism is supplied. The new automated immunochemiluminescent method for the active vitamin B12 determination is described. Reference intervals for the holotranscobalamin and related indices that can be used for the differential diagnosis of anemia of pregnancy are specified.

Highlights

  • ■ В статье представлены современные данные о роли витамина В12, в частности его биологически активной формы холотранскобаламина, в развитии анемии беременных

  • Reference intervals for the holotranscobalamin and related indices that can be used for the differential diagnosis of anemia of pregnancy are specified

  • Nexo E., Hvas A.-M., Bleie Ø., Refsum H., Fedosov S

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Summary

Introduction

■ В статье представлены современные данные о роли витамина В12, в частности его биологически активной формы холотранскобаламина, в развитии анемии беременных. The role of active vitamin B12 (holotranscobalamin) in the development of anemia of pregnancy В патогенезе развития анемии у беременных может играть роль недостаточность фолиевой кислоты и/или вит­ амина В12. При этой форме анемии нарушается нормальное созревание клеток красного ряда, обусловленное дефицитом фолиевой кислоты или витамина В12.

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