Abstract
Parkinson disease (PD) was a common insidious neurodegenerative disorder that occurs in middle-aged and elderly people, where the dopaminergic neurons in the midbrain substantia nigra (Dopamine, DA) die over time and the main clinical manifestations are resting tremor, motor bradykinesia, rigidity and eventual inability to control motor functions [1] The specific pathogenesis of PD was complex and not yet clear, but misfolding and aggregation of α-synuclein (α-Syn) is considered to be the hallmark of PD. Since early diagnosis of the disease is difficult, this review summarizes how α-Syn is involved in several aspects into neuronal function and recent advances in targeting α-Syn for PD, providing a theoretical basis for subsequent treatment of PD.
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