Abstract
Ulcerative colitis (UC) is an idiopathic inflammatory disease that affects the colon. Current pharmacological modalities to treat UC have various side effects; therefore, there is a demand to develop a new alternative medicine that can reduce side effects and increase drug efficacy. One candidate for alternative therapy is Polysaccharide Peptide which is extracted from Ganoderma lucidum mycelium. This Polysaccaharide has an active compound of Β-1,3/1,6-D-Glucan which has strong immunomodulatory and anti-inflammatory properties. Various studies have reported that Ganoderma lucidum polysaccharides can reduce inflammatory markers such as TNF-α, IFN-γ, and IL-17A, which is produced by colonic mucosal inflammation. In addition, β-1,3/1,6-D-Glucan has shown improvements in inflammatory parameters and intestinal immunological barrier function animal studies with artificial colitis and requires further research in humans before clinical applications.
Highlights
K farmakologis saat ini untuk mengobati UC memiliki berbagai efek samping, oleh karena itu, ada kesempatan untuk mengembangkan pengobatan alternatif baru yang dapat mengurangi efek samping dan meningkatkan khasiat obat
The most common clinical manifestations in IBD patients are chronic diarrhea with or without blood, IBD is a disease with a high incidence and many studies have found correlations to be a combination between genetic, environmental, 4 Treatment of UC
The current pharmacological approach aimed to achieve clinical and histological remission by inhibiting inflammation and suppress the immune system's irregular distribution and only accessible to attempts have been made to increase the production of and ph) has allowed these products become a In Japan, this herbal formula is known as Reishi, while in China and Korea, it is known as Ling Chu or Ling Zhi 15 In Indonesia, Ganoderma lucidum has been cultivated, extracted, and studied in animals or humans
Summary
K farmakologis saat ini untuk mengobati UC memiliki berbagai efek samping, oleh karena itu, ada kesempatan untuk mengembangkan pengobatan alternatif baru yang dapat mengurangi efek samping dan meningkatkan khasiat obat. The most common clinical manifestations in IBD patients are chronic diarrhea with or without blood, IBD is a disease with a high incidence and many studies have found correlations to be a combination between genetic, environmental, 4 Treatment of UC
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